resilience

Aging individuals who have mental and emotional resilience—and who do not suffer from clinical depression—report high rates of “successful aging” even in the face of worsening physical and/or cognitive functioning.

The finding from a survey of older adults published online today in the American Journal of Psychiatry upends the stereotype of old age as a uniformly unhappy experience. And—even more surprising—the older the adult the more likely he or she was to report a high degree of successful aging. In fact, older age was associated with a higher rating of successful aging, despite worsening physical and cognitive functioning.

“It was clear to us that, even in the midst of physical or cognitive decline, individuals in our study reported feeling that their well-being had improved with age,” lead author and APA President Dilip Jeste, M.D., told Psychiatric News. “This counterintuitive increase in well-being with aging persisted even after accounting for variables like income, education, and marriage.”

In the Successful Aging Evaluation (SAGE) study, Jeste and colleagues surveyed 1,006 community-dwelling adults aged 50 to 99 in San Diego County, with an oversample of people over age 80. The adults answered a 25-minute telephone interview followed by a comprehensive mail-in survey of physical, cognitive, and psychological domains, including positive psychological traits and self-rated successful aging, scaled from 1 (lowest) to 10 (highest). The average self-rating of successful aging was 8.2, with older individuals in the cohort reporting higher rates of successful aging despite worsening physical and cognitive functioning. People with poor physical health but high resilience scores had self-ratings of successful aging similar to those of physically healthy people with low resilience. Likewise, people with poor physical functioning but no or minimal depression had scores for successful aging comparable to those of physically healthy people with moderate to severe depression.

Jeste said the message for clinicians is that an optimistic approach to the care of seniors may help reduce societal ageism. “There is considerable discussion in public forums about the financial drain on society due to rising costs of health care for older adults…. But, successfully aging older adults can be a great resource for younger generations,” he said. “Perfect physical health is neither necessary nor sufficient” for successful aging, Jeste said. “There is potential for enhancing successful aging by fostering resilience and treating or preventing depression.”

American Psychiatric Association“Association Between Older Age and More Successful Aging: Critical Role of Resilience and Depression is here. For more information on this topic go here.

University at Buffalo researcher Michael Poulin

University at Buffalo researcher Michael Poulin says rescue of the Chilean miners provides a worldwide lesson in human resilience.

While many people might assume that the men rescued from the mine in Chile might suffer from psychological problems that require therapy, the miners’ survival of the ordeal may actually provide a worldwide lesson on the remarkable strength of human resilience, says a University at Buffalo researcher. [continue reading…]

The transcription factor deltaFosB mediates resilience in the nucleus accumbens, hub of the brain’s reward circuit. It is the target of an intensive high tech screening for small molecules that tweak it, which could lead to a new class of resilience-boosting antidepressants.

Scientists have discovered a mechanism that helps to explain resilience to stress, vulnerability to depression and how antidepressants work. The new findings, in the reward circuit of mouse and human brains, have spurred a high tech dragnet for compounds that boost the action of a key gene regulator there, called deltaFosB.

A molecular main power switch – called a transcription factor – inside neurons, deltaFosB turns multiple genes on and off, triggering the production of proteins that perform a cell’s activities.

“We found that triggering deltaFosB in the reward circuit’s hub is both necessary and sufficient for resilience; it protects mice from developing a depression-like syndrome following chronic social stress,” explained Eric Nestler, M.D., of the Mount Sinai School of Medicine, who led the research team, which was funded by the  National Institute of Mental Health (NIMH). [continue reading…]